Structure of PDB 5s79 Chain B

Receptor sequence
>5s79B (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVML
RHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLR
IVLSIASGLAHLHIEIFGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLV
LWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNR
WFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI
3D structure
PDB5s79 XChem group deposition
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LU8 B V214 A233 K235 L281 T283 Y285 H286 G289 D293 L343 A353 V7 A26 K28 L74 T76 Y78 H79 G82 D86 L133 A143 BindingDB: IC50=29nM
BS02 PZO B D336 D354 R375 D126 D144 R165
BS03 PZO B D388 C449 D178 C239
BS04 PZO B M288 Y294 M81 Y87
BS05 PZO B Y294 I308 V344 G348 Y87 I101 V134 G138
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5s79, PDBe:5s79, PDBj:5s79
PDBsum5s79
PubMed
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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