Structure of PDB 5rw1 Chain B

Receptor sequence

>5rw1B (length=865) Species: 9606 (Homo sapiens)

RPPVDHGLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQG
PFHTGLLNMGKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKR
FEELQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMM
GFFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGLS
EFPENFSATGDVLSHLTSSVDLYFAHHPLHVTMLPNPSHLEAVNPVAVGK
TRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSN
LPHFRIGGSVHLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGD
SPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYK
IIRARKSIPDTYAEHLIAGGLMTQEEVSEIKSSYYAKLNDHLNNMAHYRP
PQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVEVPRELQMHSHLLKT
HVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFSQR
HAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIES
PKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGA
GPDHSSCRIERFLQMCDSAEEGVDGDTVNMFVVHPTTPAQYFHLLRRQMV
RNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVDPKKVKT
LVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCPFPLDSLQQEMSKYK
HVKDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAVGIGT
VHLHQHEDILAKTFA

3D structure

• PDB: 5rw1 PanDDA analysis group deposition of ground-state model
• Chain: B
• Resolution: 1.52 Å

Enzymatic activity

• Enzyme Commision number: 1.2.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TPP	B	Q573 L617 E619 Q643 F647	Q540 L584 E586 Q610 F614
BS02	TPP	B	H202 R203 S267 H268 L269 G311 D312 A313 S314 Q318 N345 L347 G348 H414	H174 R175 S238 H239 L240 G282 D283 A284 S285 Q289 N316 L318 G319 H385
BS03	MG	B	D312 N345 L347	D283 N316 L318

Gene Ontology

Molecular Function

• GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity
• GO:0005515 protein binding
• GO:0016491 oxidoreductase activity
• GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
• GO:0030976 thiamine pyrophosphate binding
• GO:0160166 2-oxoadipate dehydrogenase activity

Biological Process

• GO:0002244 hematopoietic progenitor cell differentiation
• GO:0006091 generation of precursor metabolites and energy
• GO:0006096 glycolytic process

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0160167 oxoadipate dehydrogenase complex

External links

• PDB: RCSB:5rw1, PDBe:5rw1, PDBj:5rw1
• PDBsum: 5rw1
• UniProt: Q96HY7|DHTK1_HUMAN 2-oxoadipate dehydrogenase complex component E1 (Gene Name=DHTKD1)