Structure of PDB 5rvz Chain B

Receptor sequence

>5rvzB (length=867) Species: 9606 (Homo sapiens)

RPPVDHGLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQG
PFHTAGLLNMGKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAK
RFEELQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESM
MGFFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGL
SEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTMLPNPSHLEAVNPVAV
GKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTL
SNLPHFRIGGSVHLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVN
GDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIM
YKIIRARKSIPDTYAEHLIAGGLMTQEEVSEIKSSYYAKLNDHLNNMAHY
RPPQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVEVPRELQMHSHLL
KTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFS
QRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSI
ESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYD
GAGPDHSSCRIERFLQMCDSAEEGVDGDTVNMFVVHPTTPAQYFHLLRRQ
MVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVDPKKV
KTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCPFPLDSLQQEMSK
YKHVKDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAVGI
GTVHLHQHEDILAKTFA

3D structure

• PDB: 5rvz PanDDA analysis group deposition
• Chain: B
• Resolution: 1.98 Å

Enzymatic activity

• Enzyme Commision number: 1.2.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TPP	B	Q594 L638 E640 Q664 F668	Q542 L586 E588 Q612 F616
BS02	TPP	B	H223 R224 S288 H289 L290 G332 D333 A334 S335 Q339 N366 L368 G369 H435	H175 R176 S240 H241 L242 G284 D285 A286 S287 Q291 N318 L320 G321 H387
BS03	MG	B	D333 N366 L368	D285 N318 L320

Gene Ontology

Molecular Function

• GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity
• GO:0005515 protein binding
• GO:0016491 oxidoreductase activity
• GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
• GO:0030976 thiamine pyrophosphate binding
• GO:0160166 2-oxoadipate dehydrogenase activity

Biological Process

• GO:0002244 hematopoietic progenitor cell differentiation
• GO:0006091 generation of precursor metabolites and energy
• GO:0006096 glycolytic process

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0160167 oxoadipate dehydrogenase complex

External links

• PDB: RCSB:5rvz, PDBe:5rvz, PDBj:5rvz
• PDBsum: 5rvz
• UniProt: Q96HY7|DHTK1_HUMAN 2-oxoadipate dehydrogenase complex component E1 (Gene Name=DHTKD1)