Structure of PDB 5qc3 Chain B

Receptor sequence
>5qc3B (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
ILPDSVDWREKGCVTEVKYQGSCGASWAFSAVGALEAQLKLKTGKLVSLS
AQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKC
QYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYR
SGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMA
RNKGNHCGIASFPSYPEILQG
3D structure
PDB5qc3 Crystal structure of human Cathepsin-S with bound ligand
ChainB
Resolution1.998 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 S25 H164 N184
Catalytic site (residue number reindexed from 1) Q20 S26 H165 N185
Enzyme Commision number 3.4.22.27: cathepsin S.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B9Y B K64 G69 F70 M71 Y118 N161 V162 N163 H164 G165 F211 K65 G70 F71 M72 Y119 N162 V163 N164 H165 G166 F212 BindingDB: IC50=235nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5qc3, PDBe:5qc3, PDBj:5qc3
PDBsum5qc3
PubMed
UniProtP25774|CATS_HUMAN Cathepsin S (Gene Name=CTSS)

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