Structure of PDB 5paf Chain B

Receptor sequence
>5pafB (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTW
YLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
3D structure
PDB5paf Crystal Structure of a Factor VIIa complex
ChainB
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H253 D302 K401 G402 D403 S404 G405
Catalytic site (residue number reindexed from 1) H41 D90 K185 G186 D187 S188 G189
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B E270 D272 E275 E280 E58 D60 E63 E68
BS02 7LR B H253 D256 G297 T299 D302 D398 S399 C400 S423 W424 G425 G427 H41 D44 G85 T87 D90 D182 S183 C184 S207 W208 G209 G211
BS03 TFA B N300 Y386 N88 Y170
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5paf, PDBe:5paf, PDBj:5paf
PDBsum5paf
PubMed
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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