Structure of PDB 5pa7 Chain B

Receptor sequence
>5pa7B (length=210) Species: 10116 (Rattus norvegicus) [Search protein sequence]
DTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEVGDAKGQIMDAVIRE
YSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFA
GLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEK
CGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDG
LEKAIYQGPS
3D structure
PDB5pa7 Crystal Structure of a COMT complex
ChainB
Resolution2.12 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D141 K144 D169 N170 E199
Catalytic site (residue number reindexed from 1) D135 K138 D163 N164 E193
Enzyme Commision number 2.1.1.6: catechol O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B G66 Y68 S72 E90 I91 A118 S119 D141 W143 G60 Y62 S66 E84 I85 A112 S113 D135 W137
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008171 O-methyltransferase activity
GO:0016206 catechol O-methyltransferase activity
Biological Process
GO:0006584 catecholamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5pa7, PDBe:5pa7, PDBj:5pa7
PDBsum5pa7
PubMed
UniProtP22734|COMT_RAT Catechol O-methyltransferase (Gene Name=Comt)

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