Structure of PDB 5oxg Chain B

Receptor sequence
>5oxgB (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
TVARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELY
NTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDT
VSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCI
ADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRV
DIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQ
QRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI
3D structure
PDB5oxg Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2.
ChainB
Resolution2.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B4B B V214 V222 A233 L263 T283 Y285 H286 E287 G289 D293 L343 V12 V20 A31 L61 T81 Y83 H84 E85 G87 D91 L141 BindingDB: IC50=26nM
BS02 CA B E413 R416 Y427 K428 E211 R214 Y225 K226
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5oxg, PDBe:5oxg, PDBj:5oxg
PDBsum5oxg
PubMed28918311
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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