Structure of PDB 5ovl Chain B

Receptor sequence
>5ovlB (length=230) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
ATAGRPAFVSRSVLVTGGNRGIGLAIARRLAADGHKVAVTHRGSGAPDDL
FGVQCDVTDSAAVDRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERF
EEVINTNLTGAFRCAQRASRTMQRKRFGRIIFIGSVSGMWGIGNQANYAA
AKAGLIGMARSISRELAKAGVTANVVAPGYIDTGALDFIPAKRVGTAEEV
AGAVSFLASEDASYIAGAVIPVDGGMGMGH
3D structure
PDB5ovl Structural rearrangements occurring upon cofactor binding in the Mycobacterium smegmatis beta-ketoacyl-acyl carrier protein reductase MabA.
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G34 S148 Y161 L168
Catalytic site (residue number reindexed from 1) G21 S135 Y148 L155
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
1.1.1.36: acetoacetyl-CoA reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B G30 N32 R33 G34 I35 R55 D69 V70 N96 A97 G98 I99 T119 I146 S148 Y161 K165 G192 I194 G17 N19 R20 G21 I22 R42 D56 V57 N83 A84 G85 I86 T106 I133 S135 Y148 K152 G179 I181
Gene Ontology
Molecular Function
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0018454 acetoacetyl-CoA reductase activity
GO:0050661 NADP binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0030497 fatty acid elongation
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:5ovl, PDBe:5ovl, PDBj:5ovl
PDBsum5ovl
PubMed29717709
UniProtP71534|MABA_MYCS2 3-oxoacyl-[acyl-carrier-protein] reductase MabA (Gene Name=mabA)

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