Structure of PDB 5osy Chain B

Receptor sequence
>5osyB (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
VRLPFSGFRLQKVLRESARDKIIFLHGKVNEGEDAVVILEKTPFQVEQVA
QLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLR
QDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPD
PSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNIL
HQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERA
HLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQ
3D structure
PDB5osy 5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.
ChainB
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.59: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AJQ B W175 E185 L206 W130 E140 L161 MOAD: ic50=0.0447uM
PDBbind-CN: -logKd/Ki=7.37,IC50=0.0430uM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
Biological Process
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5osy, PDBe:5osy, PDBj:5osy
PDBsum5osy
PubMed29676910
UniProtQ96C86|DCPS_HUMAN m7GpppX diphosphatase (Gene Name=DCPS)

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