Structure of PDB 5om9 Chain B

Receptor sequence
>5om9B (length=392) Species: 9606 (Homo sapiens) [Search protein sequence]
KEDFVGHQVLRISVADEAQVQKVKELEDLEHLQLDFWRGPAHPGSPIDVR
VPFPSIQAVKIFLESHGISYETMIEDVQSLLDEEQRSTDTFNYATYHTLE
EIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFSTGGSKRPAIWIDT
GIHSREWVTQASGVWFAKKITQDYGQDAAFTAILDTLDIFLEIVTNPDGF
AFTHSTNRMWRKTRSHTAGSLCIGVDPNRNWDAGFGLSGASSNPCSETYH
GKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEPVPDQ
DELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTIDWTYSQGIKYS
FTFELRDTGRYGFLLPASQIIPTAKETWLALLTIMEHTLNHP
3D structure
PDB5om9 Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library.
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H153 E156 R211 H280 E354
Enzyme Commision number 3.4.17.1: carboxypeptidase A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O2S B H69 R127 N144 R145 I243 Y248 E270 H153 R211 N228 R229 I327 Y332 E354
BS02 ZN B H69 E72 H196 H153 E156 H280
BS03 ZN B E302 H307 E386 H391
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5om9, PDBe:5om9, PDBj:5om9
PDBsum5om9
PubMed29057062
UniProtP15085|CBPA1_HUMAN Carboxypeptidase A1 (Gene Name=CPA1)

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