Structure of PDB 5ol0 Chain B

Receptor sequence
>5ol0B (length=263) Species: 5671 (Leishmania infantum) [Search protein sequence]
APHQEHVLGEPTLEGLAHYIREKNVRRILVLVGAGASVAAGIPDFTDAFS
LTLLREKPEIFYSIARELNLWPGHFQPTAVHHFIRLLQDEGRLLRCCTQN
IDGLEKAAGVSPELLVEAHGSFAAAACIECHTPFSIEQNYLEAMSGTVSR
CSTCGGIVKPNVVFFGENLPDAFFDALHHDAPIAELVIIIGTSMQVHPFA
LLPCVVPKSVPRVVMNRERVGGLLFRFVCRDVLFRGDCQENVVTLAEYLG
LSEALAKRMRLSD
3D structure
PDB5ol0 The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design.
ChainB
Resolution1.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P49 D50 F51 N125 D127 H144
Catalytic site (residue number reindexed from 1) P43 D44 F45 N100 D102 H119
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V188 F190 G191 E192 N193 L194 D196 F199 H222 P223 V163 F165 G166 E167 N168 L169 D171 F174 H197 P198
BS02 ZN B C152 C155 C176 C179 C127 C130 C151 C154
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5ol0, PDBe:5ol0, PDBj:5ol0
PDBsum5ol0
PubMed29543820
UniProtA0A6L0XH39

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