Structure of PDB 5oji Chain B

Receptor sequence

>5ojiB (length=260) Species: 6239 (Caenorhabditis elegans)

MPSNCRRFEGKVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEA
IEYLKNKGLTKVAGIAGHIASTDDQKKLVDFTLQKFGKINILVNNHGINP
AFGHILEVSDQVWDKLFEVNVKAGFQMTKLVHPHIAKEGGGAIIFNASYS
AYKSPPGIAAYGVTKTTLVGLTRALAMGLAKDNIRVNGIAPGVIKTKMSQ
VLWDGGEDAEKELTDIQEIALGRLGVPDDCAGTVAYLASDDSSYITGEMI
IIAGGVQARL

3D structure

• PDB: 5oji Crystal structure and catalytic characterization of the dehydrogenase/reductase SDR family member 4 (DHRS4) from Caenorhabditis elegans.
• Chain: B
• Resolution: 1.6 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): G21 S148 Y161 K165
• Catalytic site (residue number reindexed from 1): G21 S148 Y161 K165
• Enzyme Commision number: 1.1.1.184: carbonyl reductase (NADPH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	B	A17 T19 G21 I22 S41 R42 N43 N46 I69 N95 H96 G97 N146 S148 Y161 K165 P191 G192 I194 T196 M198	A17 T19 G21 I22 S41 R42 N43 N46 I69 N95 H96 G97 N146 S148 Y161 K165 P191 G192 I194 T196 M198
BS02	ISN	B	S148 Y149 I158 Y161 G192 M198 S199	S148 Y149 I158 Y161 G192 M198 S199

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004090 carbonyl reductase (NADPH) activity
• GO:0016491 oxidoreductase activity

External links

• PDB: RCSB:5oji, PDBe:5oji, PDBj:5oji
• PDBsum: 5oji
• PubMed: 29151266
• UniProt: G5EGA6|DHRS4_CAEEL Dehydrogenase/reductase SDR family member 4 (Gene Name=dhrs-4)