Structure of PDB 5ohx Chain B

Receptor sequence

>5ohxB (length=488) Species: 7460 (Apis mellifera)

QPNRPSYCTWELNATNSPHTCRTKNGDYTKIMPDILTAIGQTPLIKLNNI
PKSYGIKCEIYAKCEFLNPGGSVKDRIAYRMIQDAEDKGLLKPGCTIIEP
TSGNTGIGLAMAAAVRGYKCIIVMPEKMSDEKISTLYALGAKIIRTPTEA
SWHSPEAHISVAQKLQKEIPNSIILDQYTNPGNPLAHYDQTAIEIWKQCE
GKIDYLVAGAGTGGTISGIGRKLKELSPNIKIIAVDPKGSILDPSSDEVG
FYEVEGIGYDFIPTVLDRNVIDKWIKTEDNESLNAARMLIRQEGLLCGGS
SGAALIAALKIAKDIPEEKRMVIILPDGIRNYLTKFVSEYWMETRGFLQP
VCQNEMNKWWWNMKISNLSFDKQSLLKENTVTCQEAMHMLKNADSQLLVI
SDDNIHIKGVISLNKLTSYVISGIVKCTDFVDKAMVKQYVKVKHSATLGY
ISRVLEKEPYVIILDDEHDDAFIGIVNQFHILQFITKN

3D structure

• PDB: 5ohx Crystal structure of cystathionine beta-synthase from honeybee Apis mellifera.
• Chain: B
• Resolution: 3.2 Å

Enzymatic activity

• Enzyme Commision number: 4.2.1.22: cystathionine beta-synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	B	R8 Y11 C12 T13 W14 N20 S21 P22 H23 P185 P188 L189 Y192 R225	R4 Y7 C8 T9 W10 N16 S17 P18 H19 P181 P184 L185 Y188 R221
BS02	PLP	B	K78 N108 G215 T216 G217 T219 G263 S307 P333 D334	K74 N104 G211 T212 G213 T215 G256 S300 P326 D327

Gene Ontology

Molecular Function

• GO:0004122 cystathionine beta-synthase activity
• GO:0016829 lyase activity
• GO:0020037 heme binding
• GO:0030170 pyridoxal phosphate binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006535 cysteine biosynthetic process from serine
• GO:0019343 cysteine biosynthetic process via cystathionine
• GO:0019344 cysteine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5ohx, PDBe:5ohx, PDBj:5ohx
• PDBsum: 5ohx
• PubMed: 29275181
• UniProt: Q2V0C9|CBS_APIME Cystathionine beta-synthase (Gene Name=CBS)