Structure of PDB 5ofb Chain B

Receptor sequence
>5ofbB (length=541) Species: 9606 (Homo sapiens) [Search protein sequence]
MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDI
YAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKLAKRTPESTQIGQY
GNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTW
NARTREPVTDNVEKFAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVI
IFNLKLMDNGEPELDIISNPRDIQMAETSPEGTKPERRSFRAYAAVLYID
PRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVAR
IAEEKAREAESKARTLEVRLGLTRDSRVMLRQVQNRAITLRREADVKKRI
KEAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLE
GGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWK
DIAIAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLC
LKWRTLPFYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTFR
3D structure
PDB5ofb Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
ChainB
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C499 C502 C525 C536 C497 C500 C515 C526
BS02 ATP B N39 A43 M73 K86 G98 Q99 Y100 G101 N102 G103 L104 K105 T197 K427 N39 A43 M73 K86 G98 Q99 Y100 G101 N102 G103 L104 K105 T197 K425
BS03 MG B D69 G70 S195 D69 G70 S195
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5ofb, PDBe:5ofb, PDBj:5ofb
PDBsum5ofb
PubMed29440755
UniProtQ9Y6X9|MORC2_HUMAN ATPase MORC2 (Gene Name=MORC2)

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