Structure of PDB 5ofa Chain B

Receptor sequence
>5ofaB (length=540) Species: 9606 (Homo sapiens) [Search protein sequence]
NYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAER
REDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGL
KSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNART
REPVTDNVEKFAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIFNL
KLMDNGEPELDIISNPRDIQMAEEGTKPERRSFRAYAAVLYIDPRMRIFI
HGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAR
EAESKARTLEVRLLTRDSRVMLRQVQNRAITLRREADVKKRIKEAKQRAL
KEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGV
VGVVDVPYLVLEPRHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRG
IIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLCLKWRTLPF
QLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTF
3D structure
PDB5ofa Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
ChainB
Resolution2.57 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C499 C525 C536 C489 C515 C526
BS02 ANP B N39 A43 M73 S87 K89 G98 Q99 Y100 G101 N102 G103 L104 K105 T197 K427 N35 A39 M69 S83 K85 G94 Q95 Y96 G97 N98 G99 L100 K101 T193 K417
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5ofa, PDBe:5ofa, PDBj:5ofa
PDBsum5ofa
PubMed29440755
UniProtQ9Y6X9|MORC2_HUMAN ATPase MORC2 (Gene Name=MORC2)

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