Structure of PDB 5oc9 Chain B

Receptor sequence

>5oc9B (length=616) Species: 9606 (Homo sapiens) [Search protein sequence]

SFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEQET
LENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDD
NNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLT
SGIVIQVFPLHDSEALKKLEDTWYLKYQPIDSIRGYFGETIALYFGFLEY
FTFALIPMAVIGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWKRGCAN
MTYRWGTLLMKRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLV
SLPFVCLCLYFSLYVMMIYFDMEVWALGLHWTSVLLYVPSIIYAIVIEIM
NRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVL
KDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKAD
IDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAV
LNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCAL
IGMSPQVNAVFPESKADLILIVVAVEHALLALKFILAFAIPDKPRHIQMK
LARLEFESLEALKQQQ

3D structure

PDB

5oc9 The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	B	N444 Q445 E448 E500 E529	N421 Q422 E425 E477 E506
BS02	CA	B	E448 D497 E500 E529 D533	E425 D474 E477 E506 D510
BS03	CA	B	E259 A610 I613 D615	E242 A587 I590 D592
BS04	79M	B	I228 P231 W237 D241 K242 I245	I211 P214 W220 D224 K225 I228
BS05	79M	B	Y240 A247 S248 I574 V580 V583 F584 V595	Y223 A230 S231 I551 V557 V560 F561 V572
BS06	79M	B	T255 S563 V564 L603 F607	T238 S540 V541 L580 F584
BS07	79M	B	L557 E560	L534 E537
BS08	79M	B	E388 H399 L402 K403	E365 H376 L379 K380
BS09	79M	B	L402 F409	L379 F386

Gene Ontology

	Molecular Function
GO:0005227	calcium-activated cation channel activity
GO:0005229	intracellularly calcium-gated chloride channel activity
GO:0005254	chloride channel activity

	Biological Process
GO:0034220	monoatomic ion transmembrane transport
GO:0098655	monoatomic cation transmembrane transport
GO:1902476	chloride transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5oc9, PDBe:5oc9, PDBj:5oc9
PDBsum	5oc9
PubMed	31477691
UniProt	Q9NW15\|ANO10_HUMAN Anoctamin-10 (Gene Name=ANO10)

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