Structure of PDB 5o9h Chain B

Receptor sequence
>5o9hB (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
NTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAV
ADFLACLALPALFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATI
SADRFLLVFKPAWCQRFRGAGLAWILCAVAWGLALLLTIPSALYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTW
SARETRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKK
LDSLCVSFAYINCCINPIIYVVAGQRKSLPELLREVLTEESVVRE
3D structure
PDB5o9h Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727.
ChainB
Resolution2.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9P2 B A158 G162 L166 A128 G132 L136 PDBbind-CN: -logKd/Ki=6.62,IC50=241nM
BS02 9P2 B L125 A128 T129 L156 V159 L209 W213 P214 T217 L95 A98 T99 L126 V129 L179 W183 P184 T187 PDBbind-CN: -logKd/Ki=6.62,IC50=241nM
Gene Ontology
Molecular Function
GO:0004875 complement receptor activity
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0006935 chemotaxis
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5o9h, PDBe:5o9h, PDBj:5o9h
PDBsum5o9h
PubMed29300009
UniProtP21730|C5AR1_HUMAN C5a anaphylatoxin chemotactic receptor 1 (Gene Name=C5AR1)

[Back to BioLiP]