Structure of PDB 5o26 Chain B

Receptor sequence
>5o26B (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
KAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDEQQRF
KEEAEMLKGLQHPNIVRFYDSWESKCIVLVTELMTSGTLKTYLKRFKVMK
PKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLG
LATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEY
PYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSI
RDLLNHAFFAEDTGLRV
3D structure
PDB5o26 Crystal structure of WNK3 kinase domain in a diphosphorylated state and in complex with AMP-PNP/Mg2+
ChainB
Resolution2.379 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D275 K277 D279 N280 D294 M301 P313
Catalytic site (residue number reindexed from 1) D129 K131 D133 N134 D148 M155 P167
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B G156 A157 F158 K159 V161 E228 L229 M230 D275 K277 N280 F282 D294 G21 A22 F23 K24 V26 E82 L83 M84 D129 K131 N134 F136 D148
BS02 MG B N280 D294 N134 D148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5o26, PDBe:5o26, PDBj:5o26
PDBsum5o26
PubMed
UniProtQ9BYP7|WNK3_HUMAN Serine/threonine-protein kinase WNK3 (Gene Name=WNK3)

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