Structure of PDB 5nxb Chain B

Receptor sequence
>5nxbB (length=644) Species: 10090 (Mus musculus) [Search protein sequence]
GAYVLDDSDGLGREFDGIGAVSGGGATSRLLVNYPEPYRSEILDYLFKPN
FGASLHILKVEIGGDGQTTDGTEPSHMHYELDENYFRGYEWWLMKEAKKR
NPDIILMGLPWSFPGWLGKGFSWPYVNLQLTAYYVVRWILGAKHYHDLDI
DYIGIWNERPFDANYIKELRKMLDYQGLQRVRIIASDNLWEPISSSLLLD
QELWKVVDVIGAHYPGTYTVWNAKMSGKKLWSSEDFSTINSNVGAGCWSR
ILNQNYINGNMTSTIAWNLVASYYEELPYGRSGLMTAQEPWSGHYVVASP
IWVSAHTTQFTQPGWYYLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHQ
HSMCIRPYLPYYNVSHQLATFTLKGSLREIQELQVWYTKLGTPQQRLHFK
QLDTLWLLDGSGSFTLELEEDEIFTLTTLTTGRKGSYPPPPSSKPFPTNY
KDDFNVEYPLFSEAPNFADQTGVFEYYMNNEDREHRFTLRQVLNQRPITW
AADASSTISVIGDHHWTNMTVQCDVYIETPRSGGVFIAGRVNKGGILIRS
ATGVFFWIFANGSYRVTADLGGWITYASGHADVTAKRWYTLTLGIKGYFA
FGMLNGTILWKNVRVKYPGHGWAAIGTHTFEFAQFDNFRVEAAR
3D structure
PDB5nxb The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure.
ChainB
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.46: galactosylceramidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D477 N479 F511 D660 D453 N455 F487 D636
Gene Ontology
Molecular Function
GO:0004336 galactosylceramidase activity
Biological Process
GO:0006683 galactosylceramide catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5nxb, PDBe:5nxb, PDBj:5nxb
PDBsum5nxb
PubMed29323104
UniProtP54818|GALC_MOUSE Galactocerebrosidase (Gene Name=Galc)

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