Structure of PDB 5nwz Chain B

Receptor sequence
>5nwzB (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVK
MLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECA
AKGNLREFLRARRPPPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARN
VLVTEDNVMKIADFGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT
LGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRP
TFKQLVEALDKVLLAVSE
3D structure
PDB5nwz Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region.
ChainB
Resolution2.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D612 R616 N617 D630
Catalytic site (residue number reindexed from 1) D145 R149 N150 D163
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9CT B L473 G474 C477 K503 E520 M524 I534 V550 A553 G556 N557 L619 D630 F631 L20 G21 C24 K50 E67 M71 I81 V97 A100 G103 N104 L152 D163 F164
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5nwz, PDBe:5nwz, PDBj:5nwz
PDBsum5nwz
PubMed30108871
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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