Structure of PDB 5nw5 Chain B

Receptor sequence

>5nw5B (length=1085) Species: 559292 (Saccharomyces cerevisiae S288C)

ETRVNPRALEYWVSGEIHGLVDNESVSEFKEIIEGGLGILRQESEDYVAR
RFEVYATFNNIIPILTTKNVNEVDQKFNILIVNIESIIEICIPHLQIAQD
TLLSSSEKKNPFVIRLYVQIVRFFSAIMSNFKIVKWLTKRPDLVNKLKVI
YRWTTGALRNENSNKIIITAQVSFLRDEKFGTFFLSNEEIKPIISTFTEI
MEINSHNLIYEKLLLIRGFLSKYPKLMIETVTSWLPGEVLPRIIIGDEIY
SMKILITSIVVLLELLKKCLDFVDEHERIYQCIMLSPVCETIPEKFLSKL
PLNSYDSANLDKVTIGHLLTQQIKNYIVVKNDNKIAMDLWLSMTGLLYDS
GKRVYDLTSESNKVWFDLNNLCFINNHPKTRLMSIKVWRIITYCICTKIS
QKNQEGNKSLLSLLRTPFQMTLPYVNDPSAREGIIYHLLGVVYTAFTSNK
NLSTDMFELFWDHLITPIYEDYVFKYDSIHLQNVLFTVLHLLIGGKNADV
ALEKKHIHPMSVIASEGVKLKDISSLPPQIIKREYDKIMKVVFQAVEVAI
SNVNLAHDLILTSLKHLPEDRKDQTHLESFSSLILKVTQNNKDTPIFRDF
FGAVTSSFVYTFLDLFLRKNDSSLVNFNIQISKVGISQGNMTLDLLKDVI
RKARNETSEFLIIEKFLELDDKKTEVYAQNWVGSTLLPPNISFREFQSLA
NIVNKVPNENSIENFLDLCLKLSFPVNLFTLLHVSMWSNNNFIYFIQSYV
SKNENKLNVDLITLLKTSLPGNPELFSGLLPFLRRNKFMDILEYCIHSNP
NLLNSIPDLNSDLLLKLLPRSRASYFAANIKLFKCSEQLTLVRWLLKGQQ
LEQLNQNFSEIENVLQNASDSELEKSEIIRELLHLAMANPIEPLFSGLLN
FCIKNNMADHLDEFCGNMTSEVLFKISPELLLKLLTYKEKPNGKLLAAVI
EKIENGDDDYILELLEKIIIQKEIQILEKLKEPLLVFFLNPVSSNMQKHK
KSTNMLRELVLLYLTKPLSRSAAKKFFSMLISILPPNPNYQTIDMVNLLI
DLIKSHNRKFKDKRTYNATLKTIGKWIQESGVVHQ

3D structure

• PDB: 5nw5 Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends.
• Chain: B
• Resolution: 6.502 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	K1203 S1206 R1207 S1208	K1016 S1019 R1020 S1021	PDBbind-CN: Kd=21nM

External links

• PDB: RCSB:5nw5, PDBe:5nw5, PDBj:5nw5
• PDBsum: 5nw5
• PubMed: 28604726
• UniProt: P29539|RIF1_YEAST Telomere length regulator protein RIF1 (Gene Name=RIF1)