Structure of PDB 5niu Chain B

Receptor sequence
>5niuB (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
AFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQF
VHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMIS
YGGADYKRITVKVNAPYAAALEHHH
3D structure
PDB5niu Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.
ChainB
Resolution2.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8YZ B Y56 Q66 M115 I116 A121 D122 Y39 Q49 M98 I99 A104 D105 BindingDB: IC50=2.3nM
External links
PDB RCSB:5niu, PDBe:5niu, PDBj:5niu
PDBsum5niu
PubMed29069777
UniProtQ9NZQ7|PD1L1_HUMAN Programmed cell death 1 ligand 1 (Gene Name=CD274)

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