Structure of PDB 5nge Chain B

Receptor sequence
>5ngeB (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]
HTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLA
LQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVEN
KMKGTCVEGTIPKLFRGKMVSYSDRREDYYDIQLSIKGKKNIFESFVDYV
AVEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFL
QKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSR
CTKEEAIEHNYGGHSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLV
ERLQEEKRIEAQK
3D structure
PDB5nge Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
ChainB
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N218 C223 H464 D481
Catalytic site (residue number reindexed from 1) N9 C14 H227 D244
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8WK B D295 V296 Q297 Q351 L406 M407 R408 F409 H456 D459 N460 H461 Y465 Y514 D86 V87 Q88 Q133 L169 M170 R171 F172 H219 D222 N223 H224 Y228 Y273 MOAD: Kd=65nM
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5nge, PDBe:5nge, PDBj:5nge
PDBsum5nge
PubMed29045389
UniProtQ93009|UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (Gene Name=USP7)

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