Structure of PDB 5ncg Chain B

Receptor sequence
>5ncgB (length=113) Species: 9606 (Homo sapiens) [Search protein sequence]
GSMSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRV
VGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDAN
VFASAMMHALEVL
3D structure
PDB5ncg Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
ChainB
Resolution1.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8TB B M14 Y16 W23 N71 F77 Q79 R81 M16 Y18 W25 N73 F79 Q81 R83
BS02 8TB B M1 E3 Q4 Y38 R47 M3 E5 Q6 Y40 R49
External links
PDB RCSB:5ncg, PDBe:5ncg, PDBj:5ncg
PDBsum5ncg
PubMed33184177
UniProtQ8N8S7|ENAH_HUMAN Protein enabled homolog (Gene Name=ENAH)

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