Structure of PDB 5n9r Chain B

Receptor sequence
>5n9rB (length=347) Species: 9606 (Homo sapiens) [Search protein sequence]
MSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKS
VPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLD
NVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIK
GKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQ
LMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLV
HSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDL
SVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEA
3D structure
PDB5n9r Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.
ChainB
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8RN B Y224 D295 V296 Q297 L406 M407 R408 F409 M410 K420 H456 N460 H461 Y465 Y514 Y19 D90 V91 Q92 L201 M202 R203 F204 M205 K215 H251 N255 H256 Y260 Y309 MOAD: Kd=2.6uM
BindingDB: IC50=300nM
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5n9r, PDBe:5n9r, PDBj:5n9r
PDBsum5n9r
PubMed29200206
UniProtQ93009|UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (Gene Name=USP7)

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