Structure of PDB 5n9d Chain B

Receptor sequence

>5n9dB (length=866) Species: 7227 (Drosophila melanogaster)

LGCNVSAPSGVLERVKELMEDYSRAPDAKFQQQFRHLLSVNFEEFVAETK
ERNADLDWVNPKLDERLQLELGQRQLEENAKKRLEARKKLPTMKYADDII
QAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPRRI
SAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQL
QSDPLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSATV
REQDFCDYFNNCPMFRIEGVMFPVKMLYLEDVLSKTNYEFQKFRDRRPKR
DPPERRMKHEAMIEPYLRRIRNSYDSRVLDKLRLPESEGCEDIDFIADLV
YYICENEPEGAILVFLPGYDKISQLYNILDKPKTSKGQRWRDHMAVFPLH
SLMQSGEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKAT
NYDIETNIQSLDEVWVTKANTQQRRGRAGRVRPGICYNLFSRAREDRMDD
IPTPEILRSKLESIILSLKLLHIDDPYRFLQTLINAPNPEAIKMGVELLK
RIEALDQTGTLTPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAAL
SFKSPFYSPLGKESRVDEIKRRMARNMRSDHLMVHNTIIAYRDSRYSHAE
RDFCYKNFLSSMTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEK
IPLLRAIIGAGLYPNMAHLRKSRQIKNRVRAIHTMATDDGRRVNFHPSSV
NSGESGFDSAYFVYFQRQKSTDLFLLDSTMVFPMALIIFGDGVEAGVTQN
TPYLCVAKTYYFKCNRETADVVIQLRSNLEKLLLKKALYPAPIEENGYEK
QLIKAIELLLSLDERL

3D structure

• PDB: 5n9d Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model.
• Chain: B
• Resolution: 2.71 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	R211 R212 Q237 R239 K244 T255 G257 V258 Q261 Q262 Q264 S265 G431 Y432 H463 S464 L465 T489 S495 K511 T513 L524 P635 I636 S664 D680 R793 H809 P810 S811 S833	R148 R149 Q174 R176 K181 T192 G194 V195 Q198 Q199 Q201 S202 G368 Y369 H400 S401 L402 T426 S432 K448 T450 L461 P572 I573 S601 D617 R730 H746 P747 S748 S770

Gene Ontology

Molecular Function

• GO:0002151 G-quadruplex RNA binding
• GO:0003676 nucleic acid binding
• GO:0003678 DNA helicase activity
• GO:0003723 RNA binding
• GO:0003724 RNA helicase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0051880 G-quadruplex DNA binding

Biological Process

• GO:0032508 DNA duplex unwinding
• GO:0044806 G-quadruplex DNA unwinding

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:5n9d, PDBe:5n9d, PDBj:5n9d
• PDBsum: 5n9d
• PubMed: 29429875
• UniProt: Q8SWT2