Structure of PDB 5n6c Chain B

Receptor sequence
>5n6cB (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
KVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSAT
KVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAA
ELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIG
REVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHT
PLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGA
ALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDM
3D structure
PDB5n6c Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH).
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N102 R236 D260 E265 H283
Catalytic site (residue number reindexed from 1) N95 R229 D253 E258 H276
Enzyme Commision number 1.1.1.37: malate dehydrogenase.
1.1.1.399: 2-oxoglutarate reductase.
1.1.1.95: phosphoglycerate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B G152 G154 R155 I156 Y174 D175 P176 I177 H206 T207 P208 T213 C234 A235 R236 H283 G285 G145 G147 R148 I149 Y167 D168 P169 I170 H199 T200 P201 T206 C227 A228 R229 H276 G278 MOAD: Ka=22500M^-1
Gene Ontology
Molecular Function
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:5n6c, PDBe:5n6c, PDBj:5n6c
PDBsum5n6c
PubMed29262655
UniProtO43175|SERA_HUMAN D-3-phosphoglycerate dehydrogenase (Gene Name=PHGDH)

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