Structure of PDB 5n69 Chain B

Receptor sequence
>5n69B (length=765) Species: 9913 (Bos taurus) [Search protein sequence]
EMAAFGEAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKEEFVKATILSR
EGGKVTAETEHGKTVTVKEDQVLQQNPPKFDKIEDMAMLTFLHEPAVLYN
LKERYASWMIYTYSGLFCVTINPYKWLPVYNAEVVAAYRGKKRSEAPPHI
FSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAITLE
DQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYL
LEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGE
TTVASIDDAEELMATDNAFDVLGFTTEEKNSMYKLTGAIMHFGNMKFKLK
REEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ
QVVYAKGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIF
DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQ
ACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSSNFQKPRN
IKGKPEAHFSLIHYAGTVDYNIIGWLQKNKDPLNETVVDLYKKSSLKMLS
SLFANQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVIDNPLV
MHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPDSRKGAEK
LLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRG
VLSRMEFKKLLERRD
3D structure
PDB5n69 Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil.
ChainB
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S180 G181 T185 N238 S241 S242 G464 E466
Catalytic site (residue number reindexed from 1) S176 G177 T181 N221 S224 S225 G446 E448
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B N126 P127 W130 G181 G183 K184 T185 V186 N238 N122 P123 W126 G177 G179 K180 T181 V182 N221
BS02 MG B T185 S242 T181 S225
BS03 2OW B K146 N160 Y164 T167 D168 H666 P710 N711 R712 I713 L770 K142 N156 Y160 T163 D164 H627 P671 N672 R673 I674 L726 MOAD: Kd=0.29uM
BS04 TCE B L302 T304 D309 K383 L285 T287 D292 K365
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:5n69, PDBe:5n69, PDBj:5n69
PDBsum5n69
PubMed28775348
UniProtQ9BE39|MYH7_BOVIN Myosin-7 (Gene Name=MYH7)

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