Structure of PDB 5n49 Chain B

Receptor sequence
>5n49B (length=114) Species: 9606 (Homo sapiens) [Search protein sequence]
AMELRLTELTRLLRSVLDQLQDKDPARIFAQPVSLKEVPDYLDHIKHPMD
FATMRKRLEAQGYKNLHEFEEDFDLIIDNCMKYNARDTVFYRAAVRLRDQ
GGVVLRQARREVDS
3D structure
PDB5n49 Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.
ChainB
Resolution1.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8LW B R585 I586 Q589 V591 S592 Y641 N642 F648 R27 I28 Q31 V33 S34 Y83 N84 F90 MOAD: ic50=450nM
PDBbind-CN: -logKd/Ki=6.33,IC50=470nM
External links
PDB RCSB:5n49, PDBe:5n49, PDBj:5n49
PDBsum5n49
PubMed28402630
UniProtO95696|BRD1_HUMAN Bromodomain-containing protein 1 (Gene Name=BRD1)

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