Structure of PDB 5n0c Chain B

Receptor sequence
>5n0cB (length=1286) Species: 1513 (Clostridium tetani) [Search protein sequence]
MPITINNFRYSDPVNNDTIIMMEPPYCKGLDIYYKAFKITDRIWIVPERY
EFGTKPEDFNPPSSLIEGASEYYDPNYLRTDSDKDRFLQTMVKLFNRIKN
NVAGEALLDKIINAIPYLGNSYSLLDKFDTNSNSVSFNLLEQDPSGATTK
SAMLTNLIIFGPGPVLNKNEVRGIVLRVDNKNYFPCRDGFGSIMQMAFCP
EYVPTFDNVIENITSLTIGKSKYFQDPALLLMHELIHVLHGLYGMQVSSH
EIIPSKQEIYMQHTYPISAEELFTFGGQDANLISIDIKNDLYEKTLNDYK
AIANKLSQVTSCNDPNIDIDSYKQIYQQKYQFDKDSNGQYIVNEDKFQIL
YNSIMYGFTEIELGKKFNIKTALSFFSMNHDPVKIPNLLDDTIYNDTEGF
NIESKDLKSEYKGQNMRVNTNAFRNVDGSGLVSKLIGLCKKELCIKIKNE
DLTFIAEKNSFSEEPFQDEIVSYNTKNKPLNFNYSLDKIIVDYNLQSKIT
LPNDRTTPVTKGIPYAPEYKSNAASTIEIHNIDDNTIYQYLYAQKSPTTL
QRITMTNSVDDALINSTKIYSYFPSVISKVNQGAQGILFLQWVRDIIDDF
TNESSQKTTIDKISDVSTIVPYIGPALNIVKQGYEGNFIGALETTGVVLL
LEYIPEITLPVIAALSIAESSTQKEKIIKTIDNFLEKRYEKWIEVYKLVK
AKWLGTVNTQFQKRSYQMYRSLEYQVDAIKKIIDYEYKIYSGPDKEQIAD
EINNLKNKLEEKANKAMININIFMRESSRSFLVNQMINEAKKQLLEFDTQ
SKNILMQYIKANSKFIGITELKKLESKINKVFSTPIPFSYSKNLDCWVDN
EEDIDVILKKSTILNLDINNDIISDISGFNSSVITYPDAQLVPGINGKAI
HLVNNESSEVIVHKAMDIEYNDMFNNFTVSFWLRVPKVSASHLEQYGTNE
YSIISSMKGSGWSVSLKGNNLIWTLKDSAGEVRQITFRDLPDKFNAYLAN
KWVFITITNDRLSSANLYINGVLMGSAEITGLGAIREDNNITLKLDRCNN
NNQYVSIDKFRIFCKALNPKEIEKLYTSYLSITFLRDFWGNPLRYDTEYY
LIPVASSSKDVQLKNITDYMYLTNAPSYTNGKLNIYYRRLYNGLKFIIKR
YTPNNEIDSFVKSGDFIKLYVSYNNNEHIVGYPKDGNAFNNLDRILRVGY
NAPGIPLYKKMEAVKLRDLKTYSVQLKLYDDKNASLGLVGTHNGQIGNDP
NRDILIASNWYFNHLKDKILGCDWYFVPTDEGWTND
3D structure
PDB5n0c The structure of the tetanus toxin reveals pH-mediated domain dynamics.
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) A922 K996
Catalytic site (residue number reindexed from 1) A899 K967
Enzyme Commision number 3.4.24.68: tentoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL B D1222 T1270 H1271 W1289 Y1290 D1193 T1241 H1242 W1260 Y1261
BS02 ZN B H233 H237 H233 H237
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0008320 protein transmembrane transporter activity
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0006508 proteolysis
GO:0044079 symbiont-mediated perturbation of host neurotransmitter secretion
GO:0071806 protein transmembrane transport
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5n0c, PDBe:5n0c, PDBj:5n0c
PDBsum5n0c
PubMed28645943
UniProtP04958|TETX_CLOTE Tetanus toxin (Gene Name=tetX)

[Back to BioLiP]