Structure of PDB 5mym Chain B

Receptor sequence
>5mymB (length=200) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
RRTARPSGDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFY
FPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETF
GSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPR
TLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE
3D structure
PDB5mym Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.
ChainB
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HYV B G106 F110 F114 G124 Q125 R128 W138 T149 N176 N179 E180 L183 F184 W207 G92 F96 F100 G110 Q111 R114 W124 T135 N162 N165 E166 L169 F170 W193 MOAD: ic50=3.9uM
PDBbind-CN: -logKd/Ki=5.41,IC50=3.9uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:5mym, PDBe:5mym, PDBj:5mym
PDBsum5mym
PubMed29018348
UniProtP9WMC1|ETHR_MYCTU HTH-type transcriptional regulator EthR (Gene Name=ethR)

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