Structure of PDB 5mwj Chain B

Receptor sequence
>5mwjB (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
YFQGAMGSKPAYSFHVMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCA
VTISNPTRHVYTGGKGCVKVWDISKSPVSQLDCLNRDNYIRSCKLLPDGC
TLIVGGEASTLSIWDLTPRIKAELTSSAPACYALAISPDSKVCFSCCSDG
NIAVWDLHNQTLVRQFQGHTDGASCIDISGTKLWTGGLDNTVRSWDLREG
RQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHE
SCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS
VDDKYIVTGSGDKKATVYEVIY
3D structure
PDB5mwj Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1.
ChainB
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EBU B C488 R534 Y578 L636 F661 L743 C49 R91 Y132 L188 F213 L295 MOAD: Kd=24.7nM
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:5mwj, PDBe:5mwj, PDBj:5mwj
PDBsum5mwj
PubMed28326635
UniProtQ04724|TLE1_HUMAN Transducin-like enhancer protein 1 (Gene Name=TLE1)

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