Structure of PDB 5mwh Chain B

Receptor sequence
>5mwhB (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]
MQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFT
MKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGA
VLRQARRQAEKM
3D structure
PDB5mwh Structure-based discovery of selective BRPF1 bromodomain inhibitors.
ChainB
Resolution1.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UWX B I652 F653 V657 P658 E661 N708 F714 I25 F26 V30 P31 E34 N81 F87 MOAD: Kd=1.8uM
BindingDB: Kd=2700nM,IC50=1900nM
External links
PDB RCSB:5mwh, PDBe:5mwh, PDBj:5mwh
PDBsum5mwh
PubMed29902720
UniProtP55201|BRPF1_HUMAN Peregrin (Gene Name=BRPF1)

[Back to BioLiP]