Structure of PDB 5mst Chain B

Receptor sequence
>5mstB (length=632) Species: 679197 (Segniliparus rugosus ATCC BAA-974) [Search protein sequence]
QSLAERVARLVAIDPQAAAAVPDKAVAERATQQGLRLAQRIEAFLSGYGD
RPALAQRAFEITKDPITGRAVATLLPKFETVSYRELLERSHAIASELANH
AEAPVKAGEFIATIGFTSTDYTSLDIAGVLLGLTSVPLQTGATTDTLKAI
AEETAPAVFGASVEHLDNAVTTALATPSVRRLLVFDYRQGVDEDREAVEA
ARSRLAEAGSAVLVDTLDEVIARGRALPRVALPPATDAGDDSLSLLIYTS
GTPKGAMYPERNVAQFWGGIWHNAFDDGDSAPDVPDIMVNFMPLSHVAGR
IGLMGTLSSGGTTYFIAKSDLSTFFEDYSLARPTKLFFVPRICEMIYQHY
QSELDRIGAADGSPQAEAIKTELREKLLGGRVLTAGSGSAPMSPELTAFI
ESVLQVHLVDGYGSTEAGPVWRDRKLVKPPVTEHKLIDVPELGYFSTDSP
YPRGELAIKTQTILPGYYKRPETTAEVFDEDGFYLTGDVVAEVAPEEFVY
VDRRKNVLKLSQGEFVALSKLEAAYGTSPLVRQISVYGSSQRSYLLAVVV
PTPEALAKYGDGEAVKSALGDSLQKIAREEGLQSYEVPRDFIIETDPFTI
ENGILSDAGKTLRPKVKARYGERLEALYAQLA
3D structure
PDB5mst Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.
ChainB
Resolution1.72 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T265 F285 H315 T434 L529 K629
Catalytic site (residue number reindexed from 1) T249 F266 H296 T415 L510 K610
Enzyme Commision number 1.2.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B A494 F497 A475 F478
BS02 CA B Y203 D234 Y187 D218
BS03 FUM B H315 S408 G430 Y431 G432 H296 S389 G411 Y412 G413
BS04 AMP B H315 S408 A409 P410 G430 Y431 G432 S433 T434 D507 Y519 R522 K629 H296 S389 A390 P391 G411 Y412 G413 S414 T415 D488 Y500 R503 K610
Gene Ontology
Molecular Function
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0031177 phosphopantetheine binding
GO:0050661 NADP binding
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0006629 lipid metabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mst, PDBe:5mst, PDBj:5mst
PDBsum5mst
PubMed28719588
UniProtE5XP76|CAR_SEGRC Carboxylic acid reductase (Gene Name=car)

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