Structure of PDB 5mra Chain B

Receptor sequence
>5mraB (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
MDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSM
LDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTT
MGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQ
GVVNFPYDDFIQCVMSV
3D structure
PDB5mra Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.
ChainB
Resolution3.74 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F95 G118 V120
Catalytic site (residue number reindexed from 1) F64 G87 V89
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D83 D85 S87 T89 E94 D52 D54 S56 T58 E63
BS02 DM2 B F134 R174 Q181 G182 F103 R143 Q150 G151 PDBbind-CN: -logKd/Ki=8.00,Kd=10nM
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:5mra, PDBe:5mra, PDBj:5mra
PDBsum5mra
PubMed28726784
UniProtP30626|SORCN_HUMAN Sorcin (Gene Name=SRI)

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