Structure of PDB 5mpf Chain B

Receptor sequence
>5mpfB (length=202) Species: 9606 (Homo sapiens) [Search protein sequence]
NNFEYTLEASKSLRQKSTMTYLNKGQFYPITLKEVSSKVRSVIMVVFAED
KSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNVEEIAYNAISF
TWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQIDTYSYNNRSNKPVH
RAYCQIKVFCDKGAERKIRDEERKQSKRKMDITVFKPFIDLDTQPVLFIP
DV
3D structure
PDB5mpf Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
ChainB
Resolution2.918 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Q385 K386 G387 V388 R430 Q124 K125 G126 V127 R169 PDBbind-CN: Kd=90nM
BS02 dna B T380 C421 R427 K428 T119 C160 R166 K167 PDBbind-CN: Kd=90nM
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:5mpf, PDBe:5mpf, PDBj:5mpf
PDBsum5mpf
PubMed29309642
UniProtQ9NZI5|GRHL1_HUMAN Grainyhead-like protein 1 homolog (Gene Name=GRHL1)

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