Structure of PDB 5mnv Chain B

Receptor sequence
>5mnvB (length=394) Species: 1890 (Streptomyces antibioticus) [Search protein sequence]
VPAYPFSLPHALDLDPHYAELRRDEPVSRVRLPYGEGTAWLVTRMSDARI
VLGDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFT
ARRVEEMRPRVRSLVDSLLDDMVAHGSPADLVEFLAVPFPVAVICELLGV
PLEDRDLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPTE
DLLGALALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTE
RKRYESLVADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRA
GEPCVVHFASANRDEEVFDHADELDFHRERNPHIAFGHGAHHCIGAQLGR
LELQEALSALVRRFPTLDLAEPVAGLKWKQGMLIRGLERQIVSW
3D structure
PDB5mnv Substrate-induced conformational change in cytochrome P450 OleP.
ChainB
Resolution2.97 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S180 A244 E247 T248 S249 S292 C356 I357 G358 E365 I397
Catalytic site (residue number reindexed from 1) S167 A231 E234 T235 S236 S279 C343 I344 G345 E352 I384
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B L94 H101 R105 A244 G245 T248 R298 A348 F349 G350 H354 C356 G358 L81 H88 R92 A231 G232 T235 R285 A335 F336 G337 H341 C343 G345
BS02 DEB B F84 L94 S240 I243 A244 S295 F296 F71 L81 S227 I230 A231 S282 F283
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5mnv, PDBe:5mnv, PDBj:5mnv
PDBsum5mnv
PubMed30207799
UniProtQ59819

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