Structure of PDB 5mk2 Chain B

Receptor sequence
>5mk2B (length=361) Species: 9606 (Homo sapiens) [Search protein sequence]
MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLEL
LRQNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIF
SGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCA
AGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKS
FLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAA
VAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRF
TMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPA
VTGPDIFAKLV
3D structure
PDB5mk2 Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E137 K141 Q148 K192 R198 K199 L202 L338 E137 K141 Q148 K192 R198 K199 L202 L338
Gene Ontology
Biological Process
GO:0071985 multivesicular body sorting pathway

View graph for
Biological Process
External links
PDB RCSB:5mk2, PDBe:5mk2, PDBj:5mk2
PDBsum5mk2
PubMed28602823
UniProtQ9H3S7|PTN23_HUMAN Tyrosine-protein phosphatase non-receptor type 23 (Gene Name=PTPN23)

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