Structure of PDB 5mh6 Chain B

Receptor sequence
>5mh6B (length=306) Species: 523841 (Haloferax mediterranei ATCC 33500) [Search protein sequence]
IERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGH
RDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGY
MLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGVVD
RAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDE
TEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVF
SEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDE
LTNRVV
3D structure
PDB5mh6 Productive ternary complexes of D-2-hydroxyacid dehydrogenase provide insights into the chiral specificity of its reaction mechanism
ChainB
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B T132 A134 T130 A132
BS02 MG B F212 E213 M215 D243 F210 E211 M213 D241
BS03 NAD B A67 G68 T88 G144 T145 L146 R166 T197 P198 V224 A225 R226 H274 A65 G66 T86 G142 T143 L144 R164 T195 P196 V222 A223 R224 H272
BS04 7N5 B R66 A67 G68 H91 R226 H274 Y282 R64 A65 G66 H89 R224 H272 Y280
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0031406 carboxylic acid binding
GO:0051287 NAD binding
GO:0070402 NADPH binding
GO:0070404 NADH binding
Biological Process
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5mh6, PDBe:5mh6, PDBj:5mh6
PDBsum5mh6
PubMed
UniProtQ2VEQ7|DDH_HALMT D-2-hydroxyacid dehydrogenase (Gene Name=ddh)

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