Structure of PDB 5mfw Chain B

Receptor sequence
>5mfwB (length=253) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVK
LVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKP
FMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTY
EKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNL
TQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN
GCP
3D structure
PDB5mfw Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7M6 B P532 T535 K762 G763 P100 T103 K210 G211
BS02 7M6 B K531 P532 F533 M534 T535 L783 K99 P100 F101 M102 T103 L231
BS03 KAI B E441 Y489 P516 T518 R523 G688 S689 T690 E738 E9 Y57 P84 T86 R91 G136 S137 T138 E186 BindingDB: IC50=77nM,Ki=75.9nM,EC50=37000nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5mfw, PDBe:5mfw, PDBj:5mfw
PDBsum5mfw
PubMed28360094
UniProtP22756|GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (Gene Name=Grik1)

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