Structure of PDB 5m6n Chain B

Receptor sequence
>5m6nB (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
HMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLR
CWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLL
3D structure
PDB5m6n Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C300 C303 H320 C327 C42 C45 H62 C69
BS02 7H9 B D297 G306 L307 R308 C309 W310 E319 W323 F324 D39 G48 L49 R50 C51 W52 E61 W65 F66
External links
PDB RCSB:5m6n, PDBe:5m6n, PDBj:5m6n
PDBsum5m6n
PubMed28492317
UniProtQ13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Gene Name=BIRC2)

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