Structure of PDB 5m5j Chain B

Receptor sequence
>5m5jB (length=312) Species: 5741 (Giardia intestinalis) [Search protein sequence]
TQRHVRIGIIGGGPAGLTAGIYASRANLKTCVFVGIEHTSQMFTTTDVEN
FPSHTAIKGPALMEAIQNQAEHCGAELLYEDVHSIDVSSRPFKIVHGYEN
ETTLADALIIATGATARRLDCKGEKEYWQKGVSACAVCDSAMATGKEVVV
VGGGDVACEEATYLTKIATKVYMVLRRDKFRASAAMVKKVMNEKLIEIIY
DSAIDEIKGDGKCVTSVSIKNLKDGKTRTLNAGALYWAVGHDPQTSFLKK
GQLEQDEAGYILLKDHPTQRTSVDGVFAAGDCCDHLYRQAVVAAGSGSKA
ALDAERWLAMQE
3D structure
PDB5m5j Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX.
ChainB
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C137 C140 D141 D157 E161
Catalytic site (residue number reindexed from 1) C135 C138 D139 D155 E159
Enzyme Commision number 1.8.1.9: thioredoxin-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G13 G14 G15 P16 A17 V36 H40 T41 S42 Q43 M44 N52 D83 V84 A113 T114 G115 G282 D283 R290 Q291 A292 A295 G11 G12 G13 P14 A15 V34 H38 T39 S40 Q41 M42 N50 D81 V82 A111 T112 G113 G280 D281 R288 Q289 A290 A293
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0019430 removal of superoxide radicals
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5m5j, PDBe:5m5j, PDBj:5m5j
PDBsum5m5j
PubMed28477573
UniProtE2RU27

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