Structure of PDB 5m5e Chain B

Receptor sequence
>5m5eB (length=203) Species: 9606 (Homo sapiens) [Search protein sequence]
SQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQ
ASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLR
LMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEA
PLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRT
KPA
3D structure
PDB5m5e Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines.
ChainB
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC B R105 L106 M107 P196 R100 L101 M102 P191
BS02 MAN B R183 T193 W194 R178 T188 W189
BS03 CYS B H116 E118 N123 C168 H111 E113 N118 C163
Gene Ontology
Molecular Function
GO:0004896 cytokine receptor activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5m5e, PDBe:5m5e, PDBj:5m5e
PDBsum5m5e
PubMed28405498
UniProtP14784|IL2RB_HUMAN Interleukin-2 receptor subunit beta (Gene Name=IL2RB)

[Back to BioLiP]