Structure of PDB 5m5b Chain B

Receptor sequence
>5m5bB (length=245) Species: 64320 (Zika virus) [Search protein sequence]
ETLGEKWKARLNQMSALEFYSYKKSGITEVCHAVSRGSAKLRWLVERGYL
QPYGKVIDLGCGRGGWSYYAATIRKVQEVKGYTKGGPGHEEPMLVQSYGW
NIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLRVLSMVGDW
LEKRPGAFCIKVLCPYTSTMMETLERLQRRYGGGLVRVPLSRNSTHEMYW
VSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKYEEDVNLGSGTRAV
3D structure
PDB5m5b Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
ChainB
Resolution2.01 Å
3D
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOL B G87 K111 G60 K84
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5m5b, PDBe:5m5b, PDBj:5m5b
PDBsum5m5b
PubMed28031359
UniProtA0A024B7W1|POLG_ZIKVF Genome polyprotein

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