Structure of PDB 5m4z Chain B

Receptor sequence
>5m4zB (length=286) Species: 6334 (Trichinella spiralis) [Search protein sequence]
YVNQEELNYLNQLKDIIDHGVRKNDRTGIGTLSTFGTQSRYCLRDDIFPL
LTTKRVFWRGVVEELLWFISGSTNAKQLSEKNVNIWDGNSSREFLDSRGL
YNYEEGDLGPVYGFQWRHFGCPYSSMTADYKGKGYDQLQQCIKMIREEPE
SRRIIMTAWNPCDLEKVALPPCHCFVQFYVADGELSCQMYQRSADMGLGV
PFNIASYSLLTRMIAHITSLKPGFFIHTIGDAHVYLTHVDALKVQMERKP
RPFPKLKILRNVENIDDFRAEDFELINYKPYPKISM
3D structure
PDB5m4z Molecular Mechanism of Thymidylate Synthase Inhibition by N 4 -Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies.
ChainB
Resolution1.179 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) E81 W103 Y129 C189 R209 D212
Catalytic site (residue number reindexed from 1) E64 W86 Y112 C172 R192 D195
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7K8 B R169 R170 R152 R153
BS02 7K8 B R43 C189 H190 Q208 R209 S210 D212 N220 H250 Y252 R26 C172 H173 Q191 R192 S193 D195 N203 H233 Y235
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5m4z, PDBe:5m4z, PDBj:5m4z
PDBsum5m4z
PubMed33946210
UniProtQ9NDD3

[Back to BioLiP]