Structure of PDB 5m06 Chain B

Receptor sequence
>5m06B (length=248) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
ALASGVTFAGYTVVRMLGCSAMGEVYLVQHPGFPGWQALKVLSPAMAADD
EFRRRFQRETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHM
ADRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSGDQR
ILLADFGIASQPSYPAPELSAGADVDGRADQYALALTAIHLFAGAPPVDR
SPLQPPKLSAFRPDLARLDGVLSRALATAPADRFGSCREFADAMNEQA
3D structure
PDB5m06 The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 N139 N142 Q165
Catalytic site (residue number reindexed from 1) D136 N138 N141 Q161
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B V26 A39 M89 Y91 V92 V25 A38 M88 Y90 V91
BS02 CA B N142 D159 N141 D155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5m06, PDBe:5m06, PDBj:5m06
PDBsum5m06
PubMed28054744
UniProtP9WI69|PKNI_MYCTU Serine/threonine-protein kinase PknI (Gene Name=pknI)

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