Structure of PDB 5lyh Chain B

Receptor sequence
>5lyhB (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQA
KKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYYGKGTYFAVNA
NYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDL
YDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB5lyh Small Molecule Microarray Based Discovery of PARP14 Inhibitors.
ChainB
Resolution2.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7B8 B H1682 G1683 T1684 S1688 H1691 S1700 K1711 G1712 Y1714 Y1721 S1722 Y1727 H70 G71 T72 S76 H79 S88 K92 G93 Y95 Y102 S103 Y108 MOAD: ic50=0.49uM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5lyh, PDBe:5lyh, PDBj:5lyh
PDBsum5lyh
PubMed27918638
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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