Structure of PDB 5lxp Chain B

Receptor sequence
>5lxpB (length=181) Species: 9606 (Homo sapiens) [Search protein sequence]
MDMKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNS
YQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRKGTYFAVNAN
YSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLY
DTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB5lxp Small Molecule Microarray Based Discovery of PARP14 Inhibitors.
ChainB
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7AG B H1682 G1683 Y1714 F1715 A1716 Y1721 S1722 Y1727 G1751 T1774 L1782 V1784 H73 G74 Y94 F95 A96 Y101 S102 Y107 G131 T154 L162 V164 MOAD: ic50=0.76uM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5lxp, PDBe:5lxp, PDBj:5lxp
PDBsum5lxp
PubMed27918638
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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