Structure of PDB 5lwe Chain B

Receptor sequence
>5lweB (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
NFEDFYCEKNNVRQFASHFLPPLYWLVFIVGALGNSLVILVYWYCARAKT
ATDMFLLNLAIADLLFLVTLPFWAIAAATFMCKVVNSMYKMNFYSCVLLI
MCICVDRYIAIAQAMRAHTWREKRLLYSKMVCFTIWVLAAALCIPEILTK
LKSAVLALKVILGFFLPFVVMACCYTIIIHTLIQAKKSSKHKALKATITV
LTVFVLSQFPYNCILLVQTIDAYAMFISNCAVSTAIDICFQVTQAIAFFH
SCLNPVLYVFVGERFRRDLVKTLKNLGAISQAAAH
3D structure
PDB5lwe Intracellular allosteric antagonism of the CCR9 receptor.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 79K B V69 Y73 R78 T81 T83 D84 L87 I140 R144 A255 T256 V259 Y317 G321 R323 F324 V38 Y42 R47 T50 T52 D53 L56 I103 R107 A196 T197 V200 Y258 G262 R264 F265 BindingDB: IC50=2.8nM,Ki=3.7nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0016493 C-C chemokine receptor activity
Biological Process
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5lwe, PDBe:5lwe, PDBj:5lwe
PDBsum5lwe
PubMed27926729
UniProtP51686|CCR9_HUMAN C-C chemokine receptor type 9 (Gene Name=CCR9)

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