Structure of PDB 5luz Chain B

Receptor sequence
>5luzB (length=665) Species: 9606 (Homo sapiens) [Search protein sequence]
GSSSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQVYDAVGMLGIEEVTY
ENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIE
MSMRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQ
NEIKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTD
DDKYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLP
LRTKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAERE
FILNLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFP
IEVVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQF
YLDLYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQGRPSLLR
HDEVRTYFHQFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWD
VDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSL
HTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLW
SEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLKR
EPNQKAFLMSRGLHA
3D structure
PDB5luz Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.16: neurolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B D84 H88 D103 N180 A426 C428 F429 Y606 Y613 D72 H76 D91 N168 A414 C416 F417 Y591 Y598
BS02 peptide B Y222 Y339 R554 Y610 Y613 Y210 Y327 R539 Y595 Y598
BS03 ZN B H474 H478 E503 H459 H463 E488
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
Biological Process
GO:0006111 regulation of gluconeogenesis
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:1902809 regulation of skeletal muscle fiber differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5luz, PDBe:5luz, PDBj:5luz
PDBsum5luz
PubMed29183787
UniProtQ9BYT8|NEUL_HUMAN Neurolysin, mitochondrial (Gene Name=NLN)

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